Promotion Of Second Intention Wound Healing By Emu Oil Lotion:
Comparative Results With Furasin, Polysporin, And Cortisone.
University of Saskatchewan, Saskatoon, Canada.
Previous studies showed that twice-daily application
of emu oil lotion (mixture of emu oil/fat, vitamin E, and botanical oil)
immediately after creation of full-thickness skin defects delayed wound
healing 6 days later, perhaps owing to its anti-inflammatory actions. If
administration was delayed for 48 hours, a two-fold promotion of wound
contraction, epithelialization, and infiltration
of organized granulation tissue was observed. In the present study, emu oil
lotion was applied to full-thickness skin defects in rodents 24 hours after
surgery. Six days postoperatively, wound contraction and infiltration of
fronts of epithelialized and granulation tissues
were assessed. Results indicated a two-fold promotion of all of the above
parameters with emu oil lotion. No such effects were exerted by pure emu
oil, furasin, cortaid,
or polysporin. Data obtained indicate promise for
emu oil lotion as an aid in treating full-thickness skin defects if applied
after the major postinflammatory stages of wound
healing have transpired.